|
KMID : 0903520080510030164
|
|
Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 3 p.164 ~ p.170
|
|
|
Inhibitory Effect on Melanin Formation, Collagenase and Elastase Activity by synthesized Coenzyme Q10 Derivatives
|
|
Choi Won-Sik
Jang Do-Yeon
Nam Seok-Woo
Eo Jin-Yong
Lee Kyoung-Ju
|
|
|
Abstract
|
|
|
|
Coenzyme Q10 and six derivatives of coenzyme Qn were synthesized and tested for their inhibitory effects on melanogenesis occurred in murine melanoma (B16/F1) cells and on collagenase/elastase activities as well. As the result, synthetic coenzyme Qn showed a potent inhibitory effect on melanin formation, collagenase and elastase activities in all tested concentrations. Among these synthetic compounds, coenzyme Q1 and coenzyme Q2 potentially inhibited melanin formation and elastase activity when compared to other coenzyme Qn derivatives. For the collagenase activities, all coenzyme Qn derivatives inhibited 80-85% of controls. As compared, coenzyme Qn derivatives exhibited strong inhibitory activities with the decrease of isoprenoid unit number of coenzyme Qn derivatives except for collagenase activity. For the inhibition of collagenase activity, moiety of benzoquinone might be considered as the active functional group. Taken together, coenzyme Q1 and coenzyme Q2 might be used for functional cosmetics.
|
|
|
KEYWORD
|
|
|
Coenzyme Qn, Coenzyme Q10, Elastase, Collagenase, melanin, Skin aging
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|